Epigenetics of Ancient DNA
نویسندگان
چکیده
منابع مشابه
Epigenetics of Ancient DNA
Initially, the study of DNA isolated from ancient specimens had been based on the analysis of the primary nucleotide sequence. This approach has allowed researchers to study the evolutionary changes that occur in different populations and determine the influence of the environment on genetic selection. However, the improvement of methodological approaches to genome-wide analysis has opened up n...
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Research on ancient DNA (aDNA) has the potential to enable molecular biologists and archeologists to decipher certain aspects of history by direct looking into the past. However, several major problems in this field limit the applicability of aDNA studies, most importantly contamination with modern DNA and postmortem DNA degradation. In this study we extracted and analyzed aDNA obtained from ~3...
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Ancient DNA is a field of molecular evolutionary biology that usesDNA sequence data recovered frompoorly preserved organisms, usually deceased for hundreds to hundreds of thousands of years. Ancient DNA data can provide unique snapshots in time to better understand how populations and species evolve. The field was born in the early 1980s,when thefirst ancientDNAsequences were recovered from pre...
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Since the appearance of the first reports describing the isolation and cloning of DNA from a 140-year-old preserved quagga [1] and from a 2 400 year-old Egyptian mummy [2], ancient DNA has been extracted from a number of organisms preserved in a variety of ways. Sources include preserved museum specimens, frozen mammoths, a 17 million year-old Magnolia leaf, and a 130 million yearold weevil ent...
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Epigenetic mechanisms permit the stable inheritance of cellular properties without changes in DNA sequence or amount. In prostate carcinoma, epigenetic mechanisms are essential for development and progression, complementing, amplifying and diversifying genetic alterations. DNA hypermethylation affects at least 30 individual genes, while repetitive sequences including retrotransposons and select...
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ژورنال
عنوان ژورنال: Acta Naturae
سال: 2016
ISSN: 2075-8251
DOI: 10.32607/20758251-2016-8-3-72-76